JBS scientists have demonstrated that urine contains DNA from the circulation, as illustrated in the diagram on the right. This circulation-derived urine DNA which is less than 300 bp, designated as low molecular weight (LMW) urine DNA, contains tumor derived DNA if a tumor is present in the body. As shown in related publications, listed below, colon cancer markers, such as the K-ras mutations and aberrant hypermethylated vimentin DNA, and liver cancer markers, such as the p53 codon 249T mutation and HBV 171762T/1764A double mutation, have been detected in patients with colon cancer and liver cancer respectively. These exciting results present the promise for the development of new, noninvasive genetic testing for cancer screening, early detection, and disease management.

More information



Posters & Presentations