Service
Targeted NGS of HCC-associated genes
We offer NGS-based variant detection in 43 HCC-linked genes and intergenic regions. Both somatic and germline variants can be identified. Key features of the service include:
- Construction and QC of UMI libraries from cfDNA or sheared genomic DNA.
- Hybridization enrichment using two different capture probe panels, A and B (shown below).
- High (60-80%) on-target capture rates and excellent coverage uniformity, with over 99% of all target positions covered within a twofold difference of the mean.
- Sequencing at a depth required for detection of variants at specified somatic frequencies.
- Bioinformatic analyses including UMI-based read consolidation with a specified family size and variant detection.
For questions and pricing
Please send inquiries to info@jbs-science.com.
Panel A
ALB
APC
APOB
ARID1A
ARID1B
ARID2
ATM
AXIN1
BAP1
CDKN2A
CTNNB1
HNF1A
IL6ST
KEAP1
KMT2D
LRP1B
NFE2L2
PCLO
PIK3CA
RB1
RPS6KA3
TERT promoter
TP53
TSC2
Panel B
ABCC13
CCND1
CCNE1
CMYC
CMYC-PVT1 intergenic
DNAH8
EEF1A1
ERRFI1
FN1
IDH1
IDH2
LZTR1
MCL1
MET
NCOR1
PTEN
SMARCA4
TERT
VEGFA
WWP1